Nowadays substances abuse issue is one of the most important issues in general hygiene needed early intervention services, because the detrimental effects of this social crisis are so that it affects not only abusive consumer, but also their families and society. Therefore, the present study was conducted with the aim of determining the relationship between self-compassion, mindfulness and compensation for feelings of inferiority due to make change in substances abuser in Ardakan. The present study was a descriptive-correlation study using structural equation modeling. The statistical population of the study included all people who referred to Addiction Outpatient Clinic in Ardakan in 2020 who 360 of them were selected using available sampling method of research. Data were collected from the Freiburg Mindfulness Questionnaire (FMI), Wallach et al. (2006), Compensation for Feelings of Inferiority (SAIS) et al. (2007), Reiss et al. (SCS) (2011), Readiness to Change (RTC) Rowling et al. (1992). The information obtained from the questionnaires were analyzed at two levels of descriptive statistics and inferential statistics. Findings from data analysis showed that mindfulness has a significant direct effect on self-compassion, compensation for feelings of inferiority and readiness to change in drug abusers (p<0.01). Self-compassion has significant direct effect on compensation for feelings of inferiority and readiness to change (p<0.01). Also compensation for feelings of inferiority has a significant direct effect on readiness to change in drug abuser (p<0.01). Self-compassion, on the other hand, significantly mediates the relationship between mindfulness and readiness to change in drug abuser (p<0.01). In addition, compensation for feelings of inferiority significantly mediates the relationship between self-compassion and readiness to change in drug abuser (p<0.01), but it does not significantly mediate the relationship between self-compassion and readiness to change in drug abusers (p<0.01). Based on the findings, it can be concluded that psychological intervention based on self-compassion, mindfulness and compensation for feelings of inferiority are effective in improving the readiness to change in drug abusers and can be considered as appropriate therapeutic interventions used in the psychological symptoms of addiction. Keywords: Compensation for felling of inferiority, Mindfulness, Self-compassion, Readiness to change

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